The E 63 AMG saloon was unveiled at the 2009 New York International Auto Show.[50] The new performance version of the E-Class is fitted with the same powertrain as the SL63 AMG, including เครื่องยนต์ AMG's 6.2-literV8

and the SPEEDSHIFT MCT 7-speed sports automatic transmission with four driver-selectable modes including a fully manual mode. Similar to the C63 AMG, the new E 63 is more extensively modified than before, with a new, wider front axle, heavily revised suspension, and more distinct body panels.[51]

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สำหรับโฉม ปี 2012, Mercedes-Benz started offering a bi-turbo V8 version. It is the M157

เครื่องยนต์ขนาด 5.5L twin-turbo V8, that is rated at 518 hp (386 kW), which is mated to a 7-speed AMG Speedshift MCT transmission[55]